Custom Installer

I'm having trouble with my custom installs in that each user that logs into a computer is required to register the software all over again as well as set up the data source from scratch. People move around a bit here and it would be easier if I knew how to prevent configuring the software every time they sit at a new desk. I'm sure it's just something that I'm screwing up on my end... but can't figure out what. Thanks!

Brian